Modifying Risk Factors to Prevent and Treat Erectile Dysfunction
Modifying Risk Factors to Prevent and Treat Erectile Dysfunction
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DOI：
10.1111/j.1743-6109.2012.02816.x
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发表时间：
2013-01-01
影响因子：
3.5
通讯作者：
Hellstrom, Wayne J. G.
中科院分区：
文献类型：
--
作者：
Glina, Sidney;Sharlip, Ira D.;Hellstrom, Wayne J. G.
介绍。勃起功能障碍 (ED) 是 40 岁以上男性的常见症状，且患病率随着年龄的增长而增加。心脏病、糖尿病、血脂异常、高血压和抑郁症等合并症被认为是 ED 发生的主要危险因素。此外，许多可改变的生活方式因素，包括体力活动、吸烟、饮酒、糖尿病控制和肥胖，都与 ED 相关。目的。可改变的行为因素与 ED 的关联，主要是在没有公认的合并症的男性中，为预防和潜在改善 ED 患者的勃起功能的干预策略提供了可能性。结论。虽然很有趣，但对于改变生活方式风险因素如何改善勃起功能而言，大多数文献和证据在科学上并不完全令人信服。减肥可以通过其他机制逆转 ED，即减少炎症、增加血清睾酮水平以及改善情绪和自尊。目前，现有证据表明，患者教育应旨在增加锻炼、减轻体重以达到低于 30 kg/m2 的体重指数，以及戒烟以改善或恢复勃起功能，主要针对没有既定合并症的男性。当存在合并症时，生活方式的改变对于预防或减少性功能障碍可能很重要。这些修改可能包括糖尿病男性的精确血糖控制以及使用药物疗法治疗高血压和抑郁症，这些疗法不太可能引起性副作用。 Glina S、Sharlip ID 和 Hellstrom WJG。改变危险因素以预防和治疗勃起功能障碍。 《性医学杂志》2013 年；10：115-119。
Introduction. Erectile dysfunction (ED) is a common complaint in men over 40 years of age and prevalence rates increase with age. Comorbidities such as heart disease, diabetes, dyslipidemia, hypertension, and depression have been described as primary risk factors for the development of ED. Additionally, a number of modifiable lifestyle factors, including physical activity, smoking, alcohol consumption, diabetes control, and obesity, have been associated with ED. Aim. The association of modifiable behavioral factors with ED, mainly among men without recognized comorbidities, opens the possibility for intervention strategies to prevent and potentially improve erectile function in patients suffering with ED. Conclusion. While intriguing, most of the literature and evidence is not completely scientifically compelling as to how modifying lifestyle risk factors can improve erectile function. Weight loss may reverse ED through other mechanisms, namely, decreased inflammation, increased serum testosterone levels, and improved mood and self-esteem. Currently, the evidence at hand recommends that patient education should be aimed at increasing exercise, reducing weight to achieve a body mass index less than 30 kg/m2, and stopping smoking to improve or restore erectile function, mainly in men without established comorbidities. When comorbidities are present, lifestyle modifications may be important in preventing or reducing sexual dysfunction. These modifications may include precise glycemic control in diabetic men and the use of pharmacologic therapies for hypertension and depression, which are less likely to cause sexual side effects. Glina S, Sharlip ID, and Hellstrom WJG. Modifying risk factors to prevent and treat erectile dysfunction. J Sex Med 2013;10:115-119.