Flucytosine resistance is restricted to a single genetic clade of Candida albicans.
Flucytosine resistance is restricted to a single genetic clade of Candida albicans.
复制标题
氟胞嘧啶抗性仅限于白色念珠菌的单一遗传分支。
DOI：
10.1128/aac.48.1.262-266.2004
复制
发表时间：
2004
影响因子：
4.9
通讯作者：
Soll,DavidR
中科院分区：
文献类型：
--
作者：
Pujol,Claude;Pfaller,MichaelA;Soll,DavidR
人口研究表明，白色念珠菌可分为5个主要分支，类群I、II、III、SA和E。类群SA和E分别在南非和欧洲非常普遍，而类群II在美国西南部被排除在外。在每个地理位置，有几个枝并排存在，表明枝间重组很少。这些结果表明进化支特异性表型。在本研究中，我们证明了对氟胞嘧啶（5FC MIC≥32 μg/ml）的耐药性，氟胞嘧啶是一种用于治疗systemicC的抗真菌药物。此外，5FC mic≥0.5 μg / ml的所有菌株中有97%属于I组，而其他组只有3%属于I组。在所有I组分离株中，72%的5FC mic≥0.5 μg / ml，而在所有非I组分离株中，只有2%的5FC mic≥0.5 μg / ml。这些结果首次证明了临床相关性状（5FC耐药）的支系特异性，并表明虽然支系内重组可能很常见，但支系间重组很少见。
Population studies have revealed thatCandida albicanscan be separated into five major clades, groups I, II, III, SA, and E. Groups SA and E are highly prevalent in South Africa and Europe, respectively, while group II is excluded from the southwestern portion of the United State. In each geographical locale, several clades exist side by side, suggesting little interclade recombination. These results suggest clade-specific phenotypes. In the present study we demonstrate that resistance to flucytosine (5FC MIC ≥ 32 μg/ml), an antifungal used for the treatment of systemicC. albicansinfections, is restricted to clade I. In addition, while 97% of all strains for which 5FC MICs were ≥0.5 μg per ml were members of group I, only 3% were members of the other groups. 5FC MICs were ≥0.5 μg per ml for 72% of all group I isolates, while 5FC MICs were ≥0.5 μg per ml for only 2% of all non-group I isolates. These results demonstrate for the first time the clade specificity of a clinically relevant trait (5FC resistance) and suggest that while intraclade recombination may be common, interclade recombination is rare.