The disruption of hematopoiesis in tumor progression.
The disruption of hematopoiesis in tumor progression.
复制标题
肿瘤进展中造血的破坏
DOI：
10.1097/bs9.0000000000000001
复制
发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Wang X;Li Y
成人造血系统通过补充衰竭的子代细胞和诱导对传染病和肿瘤的初次免疫反应来维持体内平衡。最近的研究表明，肿瘤进展与造血系统的严重扰动有关。科学家们试图通过评估各种肿瘤中的造血干细胞和祖细胞来阐明造血发育命运的复杂机制。结果表明，肿瘤破坏了正常的造血，导致髓外造血和骨髓偏斜。髓源性抑制细胞所起的关键调节作用诱导免疫抑制。在这里，我们总结了最近的研究结果，并讨论了实体瘤造血中断的机制。
Abstract Human adult hematopoiesis maintains homeostasis by replacing depleted progeny pools and inducing a primary immune response to infectious diseases and tumors. Recent studies have shown that tumor progression is associated with profound perturbations in hematopoiesis. Scientists have sought to clarify the complex mechanisms underlying the developmental fate of hematopoiesis by assessing hematopoietic stem and progenitor cells in various tumors. Results have shown that tumors disrupt normal hematopoiesis, resulting in extramedullary hematopoiesis and myeloid skewing. The key regulatory roles played by myeloid-derived suppressor cells induce immune suppression. Here, we summarize recent findings and discuss mechanisms underlying the disruption of hematopoiesis in solid tumors.