Preliminary study of anti-infective function of a copper-bearing stainless steel
Preliminary study of anti-infective function of a copper-bearing stainless steel
复制标题
DOI：
10.1016/j.msec.2012.03.009
复制
发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
L. Ren;Ke Yang;Lei Guo;H. Chai
中科院分区：
文献类型：
--
作者：
L. Ren;Ke Yang;Lei Guo;H. Chai
在这项研究中，开发含铜不锈钢是为了减少临床种植体相关感染的发生率。设计制作了一种317L含4.5% Cu的奥氏体不锈钢（317L-Cu SS），并通过抗菌试验、共聚焦激光扫描显微镜（CLSM）和扫描电镜（SEM）观察和动物植入等方法，对其体外和体内抗感染功能进行了初步研究。结果表明，317L-Cu SS对大肠杆菌和金黄色葡萄球菌均具有较强的抑菌作用，并通过抑制铜离子从钢表面释放而在钢表面形成细菌生物膜而表现出抗感染能力。动物植入的微生物学和组织学评价进一步证明，317L-Cu SS可以明显减少细菌感染的发生，具有抗感染功能的新型外科植入材料的潜力。
In this study the copper (Cu)-bearing stainless steel was developed to reduce the incidence of implant-associated infections in clinical areas. A 317L austenitic stainless steel containing 4.5% Cu (317L-Cu SS) was designed and fabricated, and its anti-infective function was preliminarily studied both in vitro and in vivo by means of antibacterial test, confocal laser scanning microscope (CLSM) and scanning electron microscopy (SEM) observations, and animal implantation. The results indicated that the 317L-Cu SS possessed strong antibacterial rates against both Escherichia coli and Staphylococcus aureus, and showed anti-infective ability by inhibiting the formation of bacterial bio-film on surface of the steel due to the release of Cu ions from the steel surface. The microbiological and histological evaluations from animal implantation further proved that the 317L-Cu SS could obviously reduce the happening of bacterial infection, and is potential to be used as a new class of surgical implant material with anti-infective function.