Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony
Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony
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DOI：
10.1016/j.ajog.2010.08.023
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发表时间：
2011-01-01
影响因子：
9.8
通讯作者：
James, Andra H.
中科院分区：
文献类型：
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作者：
Grotegut, Chad A.;Paglia, Michael J.;James, Andra H.
目的：我们试图确定是否有严重产后出血（PPH）继发于子宫张力的妇女比没有PPH的妇女在分娩时接受更多的催产素。研究设计：接受输血的严重PPH继发于子宫张力的受试者与匹配的对照组进行比较。总催产素暴露量以浓度曲线下面积（mU/min（星）min）计算。变量比较采用配对t检验、chi(2)和逻辑回归。结果：重度PPH患者的平均催产素曲线下面积为10054 mU，对照组为3762 mU （P < 0.001）。在采用logistic回归控制种族、体重指数、入院红细胞压积、诱导状态、镁治疗和绒毛膜羊膜炎后，曲线下的催产素面积继续预测严重PPH。结论：与对照组相比，重度PPH继发于子宫张力的妇女在分娩期间暴露于催产素的显著增加。
OBJECTIVE: We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to uterine atony received greater amounts of oxytocin during labor compared to women without PPH.STUDY DESIGN: Subjects with severe PPH secondary to uterine atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min(star)min). Variables were compared using paired t test, chi(2), and logistic regression.RESULTS: Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH.CONCLUSION: Women with severe PPH secondary to uterine atony were exposed to significantly more oxytocin during labor compared to matched controls.