Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regions
Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regions
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DOI：
10.1101/lm.93205
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发表时间：
2005-05-01
影响因子：
2
通讯作者：
McGaugh, JL
中科院分区：
文献类型：
--
作者：
LaLumiere, RT;Nawar, EM;McGaugh, JL
先前的研究结果表明，基底外侧杏仁核（BLA）和伏隔核（NAc）在影响记忆巩固方面相互作用。目前的研究调查了这种相互作用是否需要在两个大脑区域同时激活多巴胺（DA）受体。在雄性Sprague-Dawley大鼠的BLA和同侧NAc壳或核中植入单侧，右侧插管（约300 g）。一周后，对大鼠进行抑制性回避（IA）任务训练，48小时后，对它们进行保留测试。训练后立即将药物注入BLA和NAc的壳或核心。训练后bla内注射DA增强了脑潴留，这是通过进入休克室的潜伏期来评估的。将一般DA受体拮抗剂顺式氟苯乙醇（Flu）注入NAc壳（而非核心）可阻断BLA注入DA诱导的记忆增强。在反向实验中，训练后在nac壳内注射DA增强了保留率，而在BLA内注射流感阻断了这种增强。这些发现表明，BLA对记忆巩固的调节需要在NAc壳区而不是核心区同时激活DA受体。同样，记忆巩固的NAc壳调制需要在BLA中同时激活DA受体。结合先前的研究结果，这些结果表明，BLA和NAc外壳的多巴胺能神经支配在记忆巩固的调节中起关键作用。
Previous findings indicate that the basolateral amygdala (BLA) and the nucleus accumbens (NAc) interact in influencing memory consolidation. The current study investigated whether this interaction requires concurrent dopamine (DA) receptor activation in both brain regions. Unilateral, right-side cannulae were implanted into the BLA and the ipsilateral NAc shell or core in male Sprague-Dawley rats (similar to 300 g). One week later, the rats were trained on an inhibitory avoidance (IA) task and, 48 h later, they were tested for retention. Drugs were infused into the BLA and NAc shell or core immediately after training. Post-training intra-BLA infusions of DA enhanced retention, as assessed by latencies to enter the shock compartment on the retention test. Infusions of the general DA receptor antagonist cis-Flupenthixol (Flu) into the NAc shell (but not the core) blocked the memory enhancement induced by the BLA infusions of DA. In the reverse experiment, post-training intra-NAc shell infusions of DA enhanced retention and Flu infusions into the BLA blocked the enhancement. These findings indicate that BLA modulation of memory consolidation requires concurrent DA receptor activation in the NAc shell but not the core. Similarly, NAc shell modulation of memory consolidation requires concurrent DA receptor activation in the BLA. Together with previous findings, these results suggest that the dopaminergic innervation of the BLA and NAc shell is critically involved in the modulation of memory consolidation.