1p34.2 rs621559 and 14q21 rs398652 leukocyte telomere length-related genetic variants contribute to glioma susceptibility
1p34.2 rs621559 and 14q21 rs398652 leukocyte telomere length-related genetic variants contribute to glioma susceptibility
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DOI：
10.1007/s11060-014-1466-6
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发表时间：
2014-05
影响因子：
3.9
通讯作者：
Yidong Chen;Chao Lu;Jinyu Wei;Sichong Han;Herui Wang;T. Jiang;Xiaoguang Qiu;Ming Yang
中科院分区：
文献类型：
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作者：
Yidong Chen;Chao Lu;Jinyu Wei;Sichong Han;Herui Wang;T. Jiang;Xiaoguang Qiu;Ming Yang
最近的全基因组关联研究已经确定了几个白细胞端粒长度（LTL）相关的单核苷酸多态性（SNP）。我们的前期研究表明，14 q21上的rs398652和1p34.2上的rs621559两个SNPs与中国人的LTL和食管鳞状细胞癌的风险相关。然而，这些遗传变异对胶质瘤风险的作用仍然未知。因此，我们研究这些遗传变异是否影响中国人胶质瘤的遗传易感性。在分析404例脑胶质瘤患者和820例频率匹配的对照的基础上，我们发现具有1p34.2 rs621559 AG或GG基因型的受试者的OR为1.82（95%CI = 1.07-3.09，P = 0.026）或2.12（95%CI = 1.26-3.56，P = 0.005）。与AA基因型相比，14 q21 rs398652 AG或GG基因型与脑胶质瘤风险增加相关（OR = 1.39，95%CI = 1.07-1.80，P = 0.012; OR = 1.52，95%CI = 1.04-2.20，P = 0.029）。总之，我们的研究结果突出了端粒在致癌作用中的可能作用。
Recent genome-wide association studies have identified several leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Our previous data demonstrated that two SNPs (rs398652 on 14q21 and rs621559 on 1p34.2) were associated with LTL and risk of esophageal squamous cell carcinoma in Chinese. However, the role of these genetic variants on glioma risk is still unknown. Therefore, we examined if these genetic variants have impact on the genetic susceptibility of glioma in Chinese. On the basis of analyzing 404 glioma patients and frequency-matched 820 controls, we found that subjects having the 1p34.2 rs621559 AG or GG genotype had an OR of 1.82 (95 % CI = 1.07–3.09, P = 0.026) or 2.12 (95 % CI = 1.26–3.56, P = 0.005) for developing glioma, respectively, compared with subjects having the rs621559 AA genotype. Similarly, the 14q21 rs398652 AG or GG genotype was associated with increased glioma risk (OR = 1.39, 95 % CI = 1.07–1.80, P = 0.012; OR = 1.52, 95 % CI = 1.04–2.20, P = 0.029) compared to AA genotype. In all, our results highlight the possible role of telomere in carcinogenesis.