RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
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RGS12 是骨肉瘤中的一种新型肿瘤抑制因子，可抑制 YAP-TEAD1-Ezrin 信号传导。
DOI：
10.1038/s41388-020-01599-z
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发表时间：
2021-04
期刊：
影响因子：
8
通讯作者：
Yang S
中科院分区：
文献类型：
--
作者：
Li Y;Liu M;Yang S;Fuller AM;Karin Eisinger-Mathason TS;Yang S
Osteosarcoma (OS) is the most common primary malignancy of the bone that predominantly affects children and adolescents. Hippo pathway is a crucial regulator of organ size and tumorigenesis. However, how Hippo pathway regulates the occurrence of osteosarcoma is largely unknown. Here, we reported the regulator of G protein signaling protein 12 (RGS12) is a novel Hippo pathway regulator and tumor suppressor of osteosarcoma. Depletion of Rgs12 promotes osteosarcoma progression and lung metastasis in an orthotopic xenograft mouse model. Our data showed that knockdown of RGS12 upregulates Ezrin expression through promoting the GNA12/13-RhoA-YAP pathway. Moreover, RGS12 negatively regulates the transcriptional activity of YAP/TEAD1 complex through its PDZ domain function to inhibit the expression and function of the osteosarcoma marker Ezrin. PDZ domain peptides of RGS12 can inhibit the development of intratibial tumor and lung metastases. Collectively, this study identifies the RGS12 is a novel tumor suppressor in osteosarcoma through inhibiting YAP-TEAD1-Ezrin signaling pathway and provides a proof of principle that targeting RGS12 may be a therapeutic strategy for osteosarcoma.
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影响因子：
10.5
作者：
Meng Z;Moroishi T;Guan KL
通讯作者：
Guan KL
DOI：
10.1016/j.bbrc.2017.05.032
发表时间：
2017-06-24
影响因子：
3.1
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Guo, Fengbo
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Berman, Seth D.;Calo, Eliezer;Lees, Jacqueline A.
通讯作者：
Lees, Jacqueline A.
影响因子：
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作者：
Bouvier C;Macagno N;Nguyen Q;Loundou A;Jiguet-Jiglaire C;Gentet JC;Jouve JL;Rochwerger A;Mattei JC;Bouvard D;Salas S
通讯作者：
Salas S
DOI：
10.1016/bs.pmbts.2015.02.002
发表时间：
2015
影响因子：
--
作者：
Jules J;Yang S;Chen W;Li YP
通讯作者：
Li YP