How important is the seizure onset zone for seizure dynamics?
How important is the seizure onset zone for seizure dynamics?
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DOI：
10.1016/j.seizure.2014.10.013
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发表时间：
2015-02-01
影响因子：
3
通讯作者：
Lehnertz, Klaus
中科院分区：
文献类型：
--
作者：
Geier, Christian;Bialonski, Stephan;Lehnertz, Klaus
目的：对癫痫网络的研究最近使人们对癫痫过程有了更深入的了解。在这里，我们调查了癫痫dynamic.Methods的个别网络节点的重要性：我们分析了颅内脑电图记录86局灶性癫痫发作与不同的解剖学发病位置。与时间分辨相关分析，我们推导出一个序列的加权癫痫网络跨越发作前，发作，发作后的时期，每个记录网站代表一个网络节点。我们评估节点的重要性与常用的中心性指标，考虑到不同的网络properties.Results：一个高度的变异性的时间演变的节点的重要性，内部和interindividually观察。然而，节点附近和远离癫痫发作区（SOZ）被评为最重要的癫痫发作动力学更经常（65%的情况下）比节点内的SOZ（35%的情况下）。结论：我们的研究结果强调了高相关性的大脑外的SOZ，但在大规模的癫痫发作动力学网络。这些网络成分的知识可能阐明个性化的治疗干预，旨在防止癫痫发作的产生和传播的目标。(C)2014年英国癫痫协会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: Research into epileptic networks has recently allowed deeper insights into the epileptic process. Here we investigated the importance of individual network nodes for seizure dynamics.Methods: We analysed intracranial electroencephalographic recordings of 86 focal seizures with different anatomical onset locations. With time-resolved correlation analyses, we derived a sequence of weighted epileptic networks spanning the pre-ictal, ictal, and post-ictal period, and each recording site represents a network node. We assessed node importance with commonly used centrality indices that take into account different network properties.Results: A high variability of temporal evolution of node importance was observed, both intra- and interindividually. Nevertheless, nodes near and far off the seizure onset zone (SOZ) were rated as most important for seizure dynamics more often (65% of cases) than nodes from within the SOZ (35% of cases).Conclusion: Our findings underline the high relevance of brain outside of the SOZ but within the large-scale epileptic network for seizure dynamics. Knowledge about these network constituents may elucidate targets for individualised therapeutic interventions that aim at preventing seizure generation and spread. (C) 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.