THE ROLE OF COMPLEMENT IN INFLAMMATION AND PHAGOCYTOSIS
THE ROLE OF COMPLEMENT IN INFLAMMATION AND PHAGOCYTOSIS
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DOI：
10.1016/0167-5699(91)90009-i
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发表时间：
1991-09-01
期刊：
影响因子：
--
通讯作者：
FRIES, LF
中科院分区：
文献类型：
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作者：
FRANK, MM;FRIES, LF
补体最为人所知的功能是能够触发强大的、协调的抗微生物反应，包括炎症、调理作用和直接裂解。作为回应，病原体已经开发出一系列令人惊讶的对策来保护自己免受补体系统的侵害，实际上是利用补体系统。在前两篇论文中研究了宿主和寄生虫之间的这种竞争。现在很清楚，补体的作用也远远超出了这个竞技场;人们越来越意识到身体对感染和创伤的综合反应。在最后两篇论文中讨论了这种整合，这两篇论文描述了补体成分（主要是C3和受体CR 1和CR2）对体液和细胞介导的反应的发展的影响，以及活化补体蛋白对血小板反应性的深远和意想不到的影响。
The ability to trigger a powerful, coordinated repertoire of anti-microbial reactions, including inflammation, opsonization and direct lysis, is the best known function of complement. In response, pathogens have developed an astonishing array of countermeasures to protect themselves from, and indeed to exploit, the complement system. This competition between host and parasite is investigated in the first two papers. It is now clear that the role of complement also extends well beyond this arena; there is a growing awareness of an integrated response by the body to infection and trauma. This integration is discussed in the final two papers, which describe the effect of complement components, primarily C3 and the receptors CR1 and CR2, on the development of humoral and cell-mediated responses, and the profound and unexpected influence of activated complement proteins on platelet reactivity.