Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos.
Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos.
复制标题
通过用吗啡啉阻断多腺苷酸化信号序列来调节同工型表达。
DOI：
10.1007/978-1-4939-6817-6_12
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zhou,Zhengfeng
中科院分区：
文献类型：
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作者：
Gong,Qiuming;Zhou,Zhengfeng
Alternative polyadenylation is increasingly being recognized as an important layer of gene regulation. Antisense-mediated modulation of alternative polyadenylation represents an attractive strategy for the regulation of gene expression as well as potential therapeutic applications. In this chapter, we describe methods to upregulate the functional Kv11.1 isoform expression by blocking intronic polyadenylation signal sequences with antisense morpholinos.
