Lung dendritic cells and host immunity to infection.
Lung dendritic cells and host immunity to infection.
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DOI：
10.1183/09031936.01.18040692
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发表时间：
2001-10
期刊：
影响因子：
--
通讯作者：
B. Lambrecht;J. Prins;H. Hoogsteden
中科院分区：
文献类型：
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作者：
B. Lambrecht;J. Prins;H. Hoogsteden
肺是许多微生物病原体的入口，针对这些病原体的进化已经产生了足够的先天性和适应性免疫应答。树突状细胞（Dendritic cells，DCs）是整合先天免疫和特异性免疫的核心细胞。这些细胞位于肺的上皮细胞和肺泡内，在那里它们受到先天免疫系统的影响。在识别和内化微生物抗原后，DC迁移到肺的引流淋巴结以启动特异性细胞和体液免疫应答。通过整合来自病原体、宿主和环境的刺激的能力，它们专门诱导保护性免疫应答，同时避免对宿主的损害。越来越清楚的是，树突状细胞参与诱导对病毒、细菌、分枝杆菌和真菌的免疫。一些病原体破坏树突状细胞的功能以逃避免疫识别。毫不奇怪，如果树突细胞功能失败，对宿主的后果是免疫缺陷。
The lung is a portal of entry for numerous microbial pathogens, against which evolution has created an adequate innate and adaptive immune response. Dendritic cells (DCs) are central to the integration of innate and specific immunity. These cells are located within the epithelium and interstitium of the lung where they are influenced by the innate immune system. Upon recognition and internalization of microbial antigens, DCs migrate to the draining lymph nodes of the lung to initiate the specific cellular and humoral immune response. By their capacity to integrate stimuli derived from the pathogen, the host and the environment, they are specialized to induce a protective immune response while at the same time avoiding damage to the host. It is becoming increasingly clear that dendritic cells are involved in the induction of immunity to viruses, bacteria, mycobacteria and fungi. Some pathogens subvert the function of dendritic cells to escape immune recognition. Not surprisingly, if dendritic cell function fails, the consequence for the host is immunodeficiency.