PARAQUAT AND 2 ENDOGENOUS ANALOGS OF THE NEUROTOXIC SUBSTANCE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE DO NOT DAMAGE DOPAMINERGIC NIGROSTRIATAL NEURONS IN THE MOUSE
PARAQUAT AND 2 ENDOGENOUS ANALOGS OF THE NEUROTOXIC SUBSTANCE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE DO NOT DAMAGE DOPAMINERGIC NIGROSTRIATAL NEURONS IN THE MOUSE
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DOI：
10.1016/0304-3940(86)90495-7
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发表时间：
1986-09-12
影响因子：
2.5
通讯作者：
JONES, K
中科院分区：
文献类型：
--
作者：
PERRY, TL;YONG, VW;JONES, K
用最大耐受剂量的N-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）或其代谢物N-甲基-4-苯基吡啶离子（MPP+）的4种不同化学类似物重复注射C57黑小鼠，以评估它们对多巴胺能黑质纹状体神经元的可能神经毒性及其引起特发性帕金森病的可能性。这4种类似物是除草剂百草枯、还原的百草枯（具有两个N-甲基-四氢吡啶部分）、N-甲基-1，2，3，4-四氢异喹啉和2-甲基-1，2，3，4-四氢-β-异喹啉。咔啉，后两种化合物可能是内源性神经毒素。纹状体多巴胺的含量，测定高性能液相色谱电化学检测一个月后注射完成，没有耗尽这4种化合物在小鼠体内。它们可能对灵长类动物有更强的神经毒性。
C57 black mice were injected repeatedly with maximal tolerated doses of 4 different chemical analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or its metabolite N-methyl-4-phenylpyridinium ion (MPP+), in order to assess their possible neurotoxicity for dopaminergic nigrostriatal neurons and their potential for causing idiopathic Parkinson''s disease. The 4 analogues were the herbicide paraquat, reduced paraquat (having two N-methyl-tetrahydropyridine moieties), N-methyl-1,2,3,4-tetrahydroisoquinoline, and 2-methyl-1,2,3,4-tetrahydro-.beta.-carboline, the latter two compounds being possible endogenous neurotoxins. Contents of striatal dopamine, measured by high-performance liquid chromatography with electrochemical detection one month after injections were completed, were not depleted by any of these 4 compounds in mice. They might conceivably prove more neurotoxic in primates.