Decrement of the N1 auditory event-related potential with stimulus repetition: habituation vs refractoriness
Decrement of the N1 auditory event-related potential with stimulus repetition: habituation vs refractoriness
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DOI：
10.1016/s0167-8760(98)00040-3
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发表时间：
1998-12-01
影响因子：
3
通讯作者：
Michie, PT
中科院分区：
文献类型：
--
作者：
Budd, TW;Barry, RJ;Michie, PT
我们研究了传统上发现的事件相关电位（ERP）的N1峰与重复的听觉刺激的结果从习惯化的过程中或从N1反应的神经元的不应期的振幅递减。这些竞争帐户的过程中的N1递减与重复不同的预测影响的变化刺激重复和刺激间隔（ISI）。这些预测进行了检查，使用短期的习惯化设计与刺激重复和ISI的阶乘组合。45名受试者接受了21个刺激序列，每个刺激序列由7个无害的音调组成，除了第六个音调是1.5 kHz之外，其余都是1 kHz。每个受试者被分配到三个ISI条件之一（1，3或10秒）。结果提供了一点支持的观点，即N1反应衰减与刺激重复反映了一个习惯化的过程。目前的结果提供了更大的支持，认为这种递减是基于单独的不应期或恢复周期的过程中，至少有两个神经发生器的活动在N1峰潜伏期范围内作出贡献。(C)1998 Elsevier Science B.V.保留所有权利。
We examined whether the amplitude decrement traditionally found for the N1 peak of the event-related potential (ERP) with repetition of auditory stimuli results from the process of habituation or from the refractory period of the neural elements underlying the N1 response. These competing accounts of the process underlying the N1 decrement with repetition differ in terms of the predicted effects of variations in stimulus repetition and interstimulus interval (ISI). These predictions were examined using a short-term habituation design with a factorial combination of stimulus repetition and ISI. Forty-five subjects received 21 stimulus trains, each consisting of seven innocuous tones, all at 1 kHz except the sixth, which was a 1.5-kHz tone. Each subject was assigned to one of three ISI conditions (either 1, 3 or 10 s). The results provide little support for the view that N1 response decrement with stimulus repetition reflects a process of habituation. The present results provide greater support for the view that this decrement is based on the separate refractory periods or recovery cycle processes of at least two neural generators contributing to activity in the N1 peak latency range. (C) 1998 Elsevier Science B.V. All rights reserved.