Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro
Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro
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DOI：
10.1016/j.ajpath.2014.02.011
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发表时间：
2014-06-01
影响因子：
6
通讯作者：
Taylor, Robert N.
中科院分区：
文献类型：
--
作者：
Menon, Ramkumar;Boldogh, Istvan;Taylor, Robert N.
早产胎膜早破（pPROM）可能导致早产（PTB）.我们研究了胎膜早破和胎膜完整的自发性PTB妇女的胎膜过早衰老（60%的足月细胞对所有三种衰老表型标记物均呈阳性，浓度高于PTB（P < 0.05）。p53染色在PTB和足月妊娠的膜中相当，而只有
Preterm prelabor rupture of the membranes (pPROM) may Lead to preterm births (PTBs). We investigated premature senescence of fetal membranes in women with pPROM and spontaneous PTB with intact membranes (60% of term cells were positive for all three senescence phenotype markers, and concentrations were higher than in PTBs (P < 0.05). p53 staining was comparable in membranes from PTB and term birth pregnancies, whereas only