Reversal of diabetes in non-obese diabetic mice without spleen cell-derived β cell regeneration
Reversal of diabetes in non-obese diabetic mice without spleen cell-derived β cell regeneration
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DOI：
10.1126/science.1123510
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发表时间：
2006-03-24
期刊：
影响因子：
56.9
通讯作者：
Philipson, LH
中科院分区：
文献类型：
--
作者：
Chong, AS;Shen, JK;Philipson, LH
β细胞的自身免疫破坏是人类1型糖尿病（T1DM）的主要原因，并在非肥胖糖尿病（NOD）小鼠中建模。许多治疗干预措施可以预防NOD小鼠中T1DM的发展，但一旦建立，很少有治疗干预措施可以诱导其逆转。据报道，用弗氏完全佐剂、半同种异体脾细胞和临时胰岛移植进行干预可治愈已确诊的T1DM NOD小鼠。使用同样的方法，我们在这里报告说，这种治疗治愈了32%的NOD小鼠的糖尿病（>340毫克每分升血糖），尽管这些小鼠的β细胞不是来自供体脾细胞。
Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.