Effects of dopamine on juvenile hormone metabolism and fitness in Drosophila virilis
Effects of dopamine on juvenile hormone metabolism and fitness in Drosophila virilis
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DOI：
10.1016/j.jinsphys.2005.04.010
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发表时间：
2005-09-01
影响因子：
2.2
通讯作者：
Rauschenbach, IY
中科院分区：
文献类型：
--
作者：
Gruntenko, NE;Karpova, EK;Rauschenbach, IY
研究了多巴胺（DA）对果蝇（Drosophila virilis）保幼激素（JH）代谢和适合度（估计为热应激（38 ℃）下的生殖力和生存力水平）的影响。DA水平的增加，通过喂养DA减少健身的野生型（WT）苍蝇在压力下，并减少JH降解年轻的WT女性，而增加它在性成熟的WT女性。3-碘-酪氨酸处理导致DA水平降低，并导致性成熟WT和热敏感（HS）突变雌性中JH降解降低（HS雌性中DA水平是WT雌性的两倍）。观察到野生型雌性动物在压力下的生存能力和正常条件下的繁殖力急剧下降，但未观察到其下降。3-碘-酪氨酸处理还减少了第8-14期卵母细胞的数量，延迟了卵母细胞向第10期的转变，并导致野生型雌性中成熟卵的积累。它也延迟了野生型的成熟，但不影响其雄性，但不影响它们的生育能力。这推进了我们对果蝇中DA调节JH代谢的理解，并表明基础DA水平在健身中起着至关重要的作用。(c)2005爱思唯尔有限公司保留所有权利。
The effects of dopamine (DA) on juvenile hormone (JH) metabolism and fitness (estimated as fecundity and viability levels under heat stress (38 degrees C)) in Drosophila virilis have been studied. An increase of DA level obtained by feeding with DA reduced fitness of wild-type (wt) flies under stress, and decreased JH degradation in young wt females while increasing it in sexually mature wt females. A decrease in DA levels resulted from 3-iodo-tyrosine treatment and caused a decrease in JH degradation in sexually mature wt and heat sensitive (hs) mutant females (DA level in hs females is twice as high in wt females). A dramatic decrease in viability under stress and fecundity under normal conditions in wt, but not Its, females was observed. 3-iodo-tyrosine treatment also reduced the number of oocytes at stages 8-14, delayed oocyte transition to stage 10 and resulted in the accumulation of mature eggs in wt females. It delayed maturation of wt, but not Its, males as well, but did not affect their fertility. This advances our understanding of the regulation of JH metabolism by DA in Drosophila and suggests a crucial role for the basal DA level in fitness. (c) 2005 Elsevier Ltd. All rights reserved.