Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci.
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci.
复制标题
己烯雌酚诱导肿瘤转化，但两个位点没有可测量的基因突变。
作者：
J. Barrett;A. Wong;J. Mclachlan
在叙利亚仓鼠胚胎细胞中同时测定了己烯雌酚诱导肿瘤转化和体细胞突变的频率。虽然己烯雌酚在诱导转化方面与苯并[a]芘一样活跃，但它未能在两个常规研究的位点诱导突变。这些结果表明，己烯雌酚可以转化细胞的基因突变的情况下。
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.