Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
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人肝细胞癌和肝硬化组织基因组中乙型肝炎病毒特异性DNA的检测。
DOI：
10.1099/0022-1317-57-1-95
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
P. Hofschneider
中科院分区：
文献类型：
--
作者：
R. Koshy;P. Maupas;R. Müller;P. Hofschneider
通过Southern（1975）描述的印迹杂交技术，在七分之三的肝细胞癌和五分之二的肝硬化样本的染色体DNA中检测到乙型肝炎病毒相关DNA。整合模式并不相同，但一些相似之处提出了是否有一些首选的病毒整合地点的问题。
Hepatitis B virus-related DNA was detected in the chromosomal DNA of three out of seven hepatocellular carcinomas and two out of five cirrhosis samples examined, by means of the blot-hybridization technique, described by Southern (1975). The integration patterns were not identical but some similarities raise the question of whether there are some preferred sites of viral integration.