Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component
Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component
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DOI：
10.1016/j.ygeno.2004.04.007
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发表时间：
2004-08-01
期刊：
影响因子：
4.4
通讯作者：
Dai, X
中科院分区：
文献类型：
--
作者：
Li, BA;Mackay, DR;Dai, X
最近对果蝇的研究发现，编码 PHD 指蛋白的 pygopus 是典型 Wingless (Wg)/Wnt 信号通路的附加核成分。在这项研究中，我们描述了小鼠 pygopus 基因 mpygo2 的分子克隆和表达分析。几乎所有成年小鼠组织中都检测到了 mpygo2 转录本，而另一种小鼠尾肌基因 mpygo1 的转录本仅在心脏组织中检测到。在胚胎发生过程中的多个发育位点观察到丰富的 mpygo2 转录本。与 Wnt-β-连环蛋白-LEF/TCF 信号通路在哺乳动物皮肤发育中所证实的作用一致，在发育中的表皮和毛囊中检测到了 mpygo2 表达，这表明 mpygo2 可能介导了小鼠皮肤中该信号通路的作用。 (C) 2004 Elsevier Inc. 保留所有权利。
Recent studies in Drosophila identified pygopus, which encodes a PHD finger protein, as an additional nuclear component of the canonical Wingless (Wg)/Wnt signaling pathway. In this study, we describe the molecular cloning and expression analysis of a mouse pygopus gene, mpygo2. mpygo2 transcripts were detected in almost all adult mouse tissues examined, whereas transcripts of another mouse pygopus gene, mpygo1, were detected only in heart tissue. Abundant mpygo2 transcripts were observed during embryogenesis in multiple developmental sites. Consistent with the demonstrated role of the Wnt-beta-catenin-LEF/TCF signaling pathway in mammalian skin development, mpygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin. (C) 2004 Elsevier Inc. All rights reserved.