Identifying transport behavior of single-molecule trajectories.
Identifying transport behavior of single-molecule trajectories.
复制标题
识别单分子轨迹的运输行为。
DOI：
10.1016/j.bpj.2014.10.005
复制
发表时间：
2014
影响因子：
3.4
通讯作者：
Sejnowski,TerrenceJ
中科院分区：
文献类型：
--
作者：
Regner,BenjaminM;Tartakovsky,DanielM;Sejnowski,TerrenceJ
Models of biological diffusion-reaction systems require accurate classification of the underlying diffusive dynamics (e.g., Fickian, subdiffusive, or superdiffusive). We use a renormalization group operator to identify the anomalous (non-Fickian) diffusion behavior from a short trajectory of a single molecule. The method provides quantitative information about the underlying stochastic process, including its anomalous scaling exponent. The classification algorithm is first validated on simulated trajectories of known scaling. Then it is applied to experimental trajectories of microspheres diffusing in cytoplasm, revealing heterogeneous diffusive dynamics. The simplicity and robustness of this classification algorithm makes it an effective tool for analysis of rare stochastic events that occur in complex biological systems.
