Genetic disorders in a paediatric hospital in Cambodia
Genetic disorders in a paediatric hospital in Cambodia
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DOI：
10.1080/03014460500075118
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发表时间：
2005-03-01
影响因子：
1.7
通讯作者：
Pises, N
中科院分区：
文献类型：
--
作者：
Guhadasan, R;Pises, N
柬埔寨是东南亚一个极不发达的国家，儿童死亡率为105/1000活产。吴哥儿童医院是柬埔寨西北部暹粒的一家儿科教学医院，作为省级儿科部门，但也为来自柬埔寨北方各省的儿童提供服务，并为来自全国各地的卫生工作者提供培训。遗传性疾病对这一儿科人口的影响进行了讨论，解决血液学领域（包括地中海贫血和其他血红蛋白病，葡萄糖-6-磷酸缺乏症和出血性疾病），多因素疾病（腭裂，先天性心脏病和神经管缺陷），和罕见的遗传性疾病和染色体综合征。今后，随着低收入国家的发展，其传染病负担开始减轻，这些疾病对儿科发病率和死亡率的影响将日益明显。在卫生资源的分配以及本科和研究生医学教育的结构中，需要考虑这种转变。
Cambodia is an extremely underdeveloped country in Southeast Asia with a childhood mortality rate of 105/1000 live births. Angkor Hospital for Children is a paediatric teaching hospital in Siem Reap, northwest Cambodia, which serves as the provincial paediatric department but also sees children from provinces throughout northern Cambodia, and with training provided for health workers from all parts of the country. The impact of genetic disease on this paediatric population is discussed, addressing the areas of haematology ( including thalassaemia and other haemoglobinopathies, glucose-6-phosphate deficiency and bleeding disorders), multifactorial disorders ( cleft palate, congenital heart disease and neural tube defects), and uncommon genetic disorders and chromosomal syndromes. In the future, as low-income countries develop and their burden of infectious disease begins to subside, the contribution of these disorders to paediatric morbidity and mortality will become increasingly apparent. This transition needs to be considered in the allocation of health resources and in the structuring of undergraduate and postgraduate medical education.