ALTERATION OF EPIDIDYMAL SPERM TRANSPORT AND MATURATION IN MICE BY ESTROGEN AND TESTOSTERONE
ALTERATION OF EPIDIDYMAL SPERM TRANSPORT AND MATURATION IN MICE BY ESTROGEN AND TESTOSTERONE
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DOI：
10.1038/258145a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
BRUCE, WR
中科院分区：
文献类型：
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作者：
MEISTRICH, ML;HUGHES, TJ;BRUCE, WR
精子在通过哺乳动物附睾的过程中成熟，包括运动、代谢、形态、生化特性和卵细胞受精能力的变化。这种成熟过程和受精能力的维持都依赖于雄激素2。当睾丸激素水平因阉割或垂体切除术而降低时，来自附睾尾的精子具有未成熟的顶体（豚鼠）3和较低的受精能力（大鼠）4。这些影响可以通过睾酮治疗来预防。由于睾酮水平的降低提高了附睾精子运输的速度4,5，不完全成熟可能是由于精子在附睾关键区域停留的时间不足，以及附睾促进精子成熟的能力下降所致。我们在这里证明，雌激素和睾丸激素通过改变附睾精子运输的速度影响小鼠精子成熟的一个方面，也影响生育能力。
THE maturation of spermatozoa during passage through the mammalian epididymis, involves changes in motility, metabolism, morphology, biochemical properties and the development of the ability to fertilise ova1. This maturation process, and the maintenance of fertilising ability, is dependent on androgen2. When testosterone levels are lowered by castration or hypophysectomy, sperm from the cauda epididymis have immature acrosomes (guinea pig)3and lowered fertilising ability (rat)4. These effects are prevented by testosterone treatment. Since reduction of testosterone levels enhances the rate of epididymal sperm transport4,5, the incomplete maturation could result from spermatozoa spending insufficient time in critical regions of the epididymis, as well as from a decreased ability of the epididymis to promote sperm maturation. We demonstrate here that oestrogen and testosterone affect one aspect of sperm maturation in mice by altering the rate of epididymal sperm transport, and also affect fertility.