Increased Platelet Aggregation due to a Plasmatic Aggregating Activity
Increased Platelet Aggregation due to a Plasmatic Aggregating Activity
复制标题
由于血浆聚集活性而增加血小板聚集
DOI：
10.1159/000214352
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发表时间：
1980
影响因子：
6.7
通讯作者：
C. Mugnaini
中科院分区：
文献类型：
--
作者：
G. G. Serneri;R. Abbate;G. Gensini;S. Favilla;C. Mugnaini
In various clinical states an increased platelet aggregation has been observed, but its mechanism(s) is not yet completely understood. Plasma of some patients with history of myocardial infarction (MIP) or with cerebrovascular disorders (CVP) delays platelet disaggregation after aggregation by ADP (Neri Serneri et al 1974) and induces morphological changes in control platelets (Schatz and Gross 1975). In a group of 27 MIP and 20 CVP we identified 16 MIP and 12 CVP with plasmatic aggregating activity (AA) by cross-matches in a modification of the method of Wu and Hoak (1974) for platelet aggregates. As the AA disappeared after heparin treatment (12,500 U × 2 for 7 days) we investigated whether the AA was related to an activation of clotting processes. At this purpose we measured in these patients and in those without AA the concentration of high molecular weight fibrinogen complexes (HMWFC) by agarose 4% gel-filtration. The patients with AA showed a significantly (P<0.0l) higher HMWFC concentration (9.68±2.15 %) than those without AA (5.41±1.7 %) but the AA was not related to the HMWFC themselves, which on the contrary showed a mild antiaggregating activity. On gel-chromatography of the whole plasma the AA was eluted at an elution volume at which factor X is usually collected.
