Vitamin D endocrine system and osteocytes.
Vitamin D endocrine system and osteocytes.
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DOI：
10.1038/bonekey.2013.228
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Erben, Reinhold G
中科院分区：
文献类型：
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作者：
Lanske, Beate;Densmore, Michael J;Erben, Reinhold G
骨细胞是三种骨细胞类型中数量最多的一种，其生理作用直到最近才被大大低估。现在已知它们不仅协调骨重塑，而且还具有内分泌功能，作为钙和磷酸盐稳态调节网络的一部分。维生素 D 和骨细胞以多种方式相互作用来完成这些活动。活性维生素 D (1,25(OH)2D3) 的主要来源是肾脏，但有证据表明骨细胞也可以产生它。 Renal 1,25(OH)2D3 调节骨细胞生成成纤维细胞生长因子 23 (FGF23)，这是一种强大的磷酸盐因子，具有深远的生理效应。对骨细胞本身产生的 1,25(OH)2D3 的功能知之甚少，这是一个活跃的研究领域。骨细胞响应机械负荷和血清 1,25(OH)2D3 等内分泌信号，产生成骨细胞和破骨细胞的调节因子，从而影响局部骨重塑。此外，1,25(OH)2D3 可能会抑制骨细胞腔隙中的矿化。目前尚不清楚 1,25(OH)2D3 是否在骨细胞腔周重塑中发挥作用。这篇简短的综述介绍了我们对维生素 D 信号在骨细胞中的生理和临床重要作用的了解现状。
The physiological role of the osteocyte, the most numerous of the three bone cell types, was significantly underestimated until recently. It is now known that they not only coordinate bone remodeling but also have an endocrine function as part of the regulatory network for calcium and phosphate homeostasis. Vitamin D and osteocytes interact in numerous ways to accomplish these activities. The major source of active vitamin D (1,25(OH)2D3) is the kidney but there is evidence that osteocytes can produce it as well. Renal 1,25(OH)2D3 regulates osteocyte production of fibroblast growth factor 23 (FGF23), a powerful phosphaturic factor with far-reaching physiological effects. The function of 1,25(OH)2D3 produced by osteocytes themselves is poorly understood and is an area of active research. Osteocytes affect local bone remodeling by producing regulatory factors for osteoblasts and osteoclasts in response to mechanical loading and to endocrine signals such as serum 1,25(OH)2D3. In addition, 1,25(OH)2D3 may inhibit mineralization in osteocyte lacunae. Whether 1,25(OH)2D3 has a role in osteocytic perilacunar remodeling is currently unknown. This short review presents the current state of our knowledge about the physiologically and clinically significant roles of vitamin D signaling in osteocytes.