Multicomponent reactions: Synthesis of spirocyclic tetrahydropyran derivatives by Prins cyclization
Multicomponent reactions: Synthesis of spirocyclic tetrahydropyran derivatives by Prins cyclization
复制标题
DOI：
10.3987/com-02-s(m)63
复制
发表时间：
2002-11-22
期刊：
影响因子：
0.6
通讯作者：
Schiltz, G
中科院分区：
文献类型：
--
作者：
Ghosh, AK;Shin, D;Schiltz, G
在非水条件下，用各种环酮、高烯丙醇、甲烷磺酸或对甲苯磺酸进行Prins环化反应，以较高的产率合成了取代螺环四氢吡喃甲磺酸酯和对甲苯磺酸酯。然后，可以使用有效的两步程序将由此产生的甲磺酸盐转化为相应的BOC保护胺。
Substituted spirocyclic tetrahydropyranyl mesylates and tosylates have been synthesized in good yields using a Prins-type cyclization of various cyclic ketones, a homoallylic alcohol and either methanesulfonic or p-toluenesulfonic acid under non-aqueous conditions. The mesylates thus produced could then be transformed into the corresponding Boc-protected amines using an efficient two step procedure.