Power Spectral Analysis of Heart-Rate Variations Improves Assessment of Diabetic Cardiac Autonomic Neuropathy
Power Spectral Analysis of Heart-Rate Variations Improves Assessment of Diabetic Cardiac Autonomic Neuropathy
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心率变化的功率谱分析改善了糖尿病心脏自主神经病变的评估
DOI：
10.2337/diab.41.5.633
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发表时间：
1992
期刊：
影响因子：
7.7
通讯作者：
K. Thomaseth
中科院分区：
文献类型：
--
作者：
F. Bellavere;I. Balzani;G. De Masi;M. Carraro;P. Carenza;C. Cobelli;K. Thomaseth
心率变化的功率谱分析（PSA）最近被证明是评估心血管自主活动的有用工具。它提供了通过分解为两个频带来检查副交感神经和交感神经通路的功能及其对心率周期性变异性的影响的可能性。我们应用 PSA 自回归模型来研究 20 名年龄匹配的男性对照受试者和 53 名胰岛素依赖型（I 型）糖尿病受试者的整体自主神经张力，将其分为三组，每组 20 人、15 人和 18 人，每组表现出不同程度的自主神经参与。我们发现 1) 在没有心脏自主神经病变 (CAN) 的糖尿病受试者和对照受试者中，高频段的功率谱密度 (PSD) 值（副交感神经依赖性）相似，但与轻度 CAN 和重度 CAN 的糖尿病受试者（站立和躺着时均存在显着差异）； 2）在没有CAN的糖尿病受试者和对照受试者中，低频（主要是交感神经依赖性）的PSD值相似或略有不同，但与轻度和重度CAN的糖尿病受试者（无论是站立还是躺着）均存在显着差异； 3) 作为副交感神经与交感神经一致性的表达，在对照组和没有 CAN 的糖尿病受试者中，站立和躺着的 PSD 值之间存在低频段和高频段的相关性，但在患有 CAN 的糖尿病受试者中则不存在相关性； 4) 糖尿病受试者中高频和低频 PSD 值与传统心血管测试值之间存在不同程度的相关性。最好的相关性是 PSD 低频值和从躺到站的动作之间的相关性。频率值和从躺到站的动作。这些数据表明 PSA 1) 可以区分不同程度的副交感神经参与，2) 可以区分不同程度的交感神经参与，3) 提供只能通过传统心血管自主测试部分探索的整体自主活动图景，4) 可以揭示副交感神经与交感神经的协同失调。这些数据表明心血管自主神经测试可能反映自主神经通路的不同方面。因此，PSA 似乎是确定糖尿病 CAN 自主神经张力的有力工具。
Power spectral analysis (PSA) of heart-rate variations has recently proved a useful tool in evaluating cardiovascular autonomic activity. It offers the possibility of examining both the functioning of parasympathetic and sympathetic pathways through breakdown into two frequency bands, and of their effects on heart-rate cyclic variability. We applied an autoregressive model for PSA to study overall autonomic tone in 20 male age-matched control subjects and 53 insulin-dependent (type I) diabetic subjects, subdivided into three groups of 20, 15, and 18, each group presenting different degrees of autonomic involvement. We found that 1) power spectrum density (PSD) values at high-frequency bands (parasympathetic dependent) were similar in diabetic subjects without cardiac autonomic neuropathy (CAN) and in control subjects, but differed significantly from diabetic subjects with mild CAN and severe CAN, both standing and lying; 2) PSD values at low frequency (mainly sympathetic dependent) were similar, or slightly different, in diabetic subjects without CAN and in control subjects, but differed significantly from diabetic subjects with mild and severe CAN, both standing and lying; 3) as an expression of parasympathetic versus sympathetic coherence, correlations, both standing and lying, existed between PSD values at low- and high-frequency bands in control and diabetic subjects without CAN, but not in diabetic subjects with CAN; and 4) different degrees of correlation characterized the PSD values of high and low frequencies versus traditional cardiovascular test values in the diabetic subjects. The best correlation was between PSD low-frequency values and the lying-to-standing maneuver. frequency values and the lying-to-standing maneuver. These data indicate that PSA 1) can discriminate between differing degrees of parasympathetic involvement, 2) can discriminate between different degrees of sympathetic involvement, and 3) offers a picture of overall autonomic activity that can be explored only partially by traditional cardiovascular autonomic tests and 4) can reveal parasympathetic versus sympathetic dyssynergia. These data suggest that cardiovascular autonomic tests may reflect different aspects of autonomic pathways. Hence, PSA appears to be a powerful tool in the determination of autonomic tone in diabetic CAN.
影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ