Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: correlation with MR imaging and angiographically assisted CT
Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: correlation with MR imaging and angiographically assisted CT
复制标题
DOI：
10.1007/s00261-005-0091-4
复制
发表时间：
2006-01-01
影响因子：
--
通讯作者：
Moriyama, N
中科院分区：
文献类型：
--
作者：
Kanematsu, M;Osada, S;Moriyama, N
我们总结和讨论我们以前的研究结果之间的相关性磁共振（MR）成像和血管造影辅助计算机断层扫描（CT）和血管内皮生长因子（VEGF）的表达强度在肝细胞癌（HCC）和周围的rionumorous肝。回顾性分析22例MR图像、20例CT门脉造影和17例CT肝动脉造影与HCC和周围肝脏VEGF表达的定量和定性相关性。在反相、T1加权、破坏梯度回波（GRE）图像上，HCC与肝脏的对比噪声比与HCC的VEGF表达指数（VEGF（IND））值呈负相关，在T2加权、快速自旋回波图像上呈直接相关，在钆增强肝动脉期GRE图像上呈轻微负相关。在T2加权快速自旋回波图像上，HCC的标准差比与HCC的VEGF（IND）值直接相关。CT肝动脉造影显示HCC的增强指数与VEGF（IND）呈中度负相关，肝脏的增强指数与VEGF（IND）呈中度正相关。肝细胞癌在图像上的异质性与反相T1加权GRE图像、T2加权快速自旋回波图像、肝动脉期GRE图像上肝细胞癌的VEGF（IND）值直接相关。平衡期GRE图像和CT肝动脉造影。我们的研究结果可能反映了HCC在CT或MR图像上的MR信号强度、肝动脉血管分布和异质性与HCC中VEGF表达的强度密切相关，因为HCC中的高或缺氧上调HCC中的VEGF表达。尽管我们的研究结果对放射学实践的真实的影响目前还存在争议。我们相信，我们的结果可能有助于将来放射学实践与生物分子或遗传治疗肝癌。
We summarize and discuss our previous research results on the correlation between findings on magnetic resonance (MR) imaging and angiographically assisted computed tomography (CT) and the intensity of vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HCC) and in the surrounding riontumorous liver. MR images (n = 22), CT during arterial portography (n = 20), and CT hepatic arteriography (n = 17) were retrospectively correlated quantitatively and qualitatively with VEGF expression in HCCs and in the surrounding liver assessed by western blotting. HCC-to-liver contrast-to-noise ratio correlated with VEGF expression index (VEGF(IND)) values of HCCs inversely on opposed-phase, T1-weighted, spoiled gradient recalled-echo (GRE) images, directly on T2-weighted, fast spin-echo images, and marginally and inversely on gadolinium-enhanced hepatic arterial-phase GRE images. On T2-weighted fast spin-echo images, standard deviation ratio of HCCs correlated directly with VEGF(IND) values of HCCs. By CT hepatic arteriography, the contrast-enhancement index of HCCs showed a moderate inverse correlation with VEGF(IND) values of HCCs, and the contrast-enhancement index of the liver showed marginal, moderate direct correlation with VEGF(IND) values in the liver. Heterogeneities of HCCs on images correlated directly with VEGF(IND) values of HCCs on opposed-phase T1-weighted GRE images, T2-weighted fast spin-echo images, hepatic arterial-phase GRE images. equilibrium-phase GRE images, and CT hepatic arteriogram. Our results may reflect that MR signal intensity, hepatic arterial vascularity, and heterogeneity of HCCs on CT or M R images are closely related to the intensity of VEGF expression in HCC as upregulated by hyper- or hypoxia in HCCs. Although the real effects of our results on radiologic practice are debatable at this moment. we believe that our results may help future radiologic practice in conjunction with biomolecular or genetic treatment for HCCs.