Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes
Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes
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Cx43和E-cadherin在胃癌及转移淋巴结中的表达及意义
DOI：
10.1007/s12032-010-9492-5
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发表时间：
2011-06-01
期刊：
影响因子：
3.4
通讯作者：
Qian, Feng
中科院分区：
文献类型：
--
作者：
Tang, Bo;Peng, Zhi-Hong;Qian, Feng
Cx43和E-cadherin在多种肿瘤中同时表达，在原发性肿瘤中被认为是肿瘤抑制因子，而近年来的研究表明这两种蛋白在肿瘤转移中起着特殊的作用。本研究的目的是检测Cx43和E-cadherin在原发性胃肿瘤（PT）和配对转移淋巴结（MLN）中的表达，并探讨这些蛋白表达的临床和病理意义。采用免疫组化法检测Cx43和E-cadherin在PTs和MLN中的表达，并分析其临床病理意义。与癌旁正常组织相比，肺癌组织中Cx43和E-cadherin的表达明显降低（P< 0.01）。与PT相比，MLN中Cx43和E-cadherin的表达显着增加（Cx43和E-cadherin的表达分别为P< 0.01和P < 0.01），并且一些Cx43和E-cadherin阴性的PT发生了Cx43和E-cadherin阳性的MLN。Cx43和E-cadherin的低表达与胃癌的低分化、TNM分期及淋巴结转移密切相关。Cx43和E-cadherin的表达呈显著相关。我们的结论是，Cx43和E-cadherin的同时减少可能有助于胃癌的发生。然而，Cx43和E-cadherin的同时表达增加可能有助于胃癌向淋巴结的有效转移。
Connexin 43(Cx43) and E-cadherin are concurrently expressed in many tumors and were ever classified as tumor suppressors in primary tumors (PT), whereas recent studies showed that these two proteins played specific roles in tumor metastasis. The aim of our study is to determine the expression of Cx43 and E-cadherin in primary gastric tumors (PTs) and matched metastatic lymph nodes (MLNs) and to explore the clinical and pathological implications of expression of these proteins. Immunohistochemical assay was conducted to detect the expression of Cx43 and E-cadherin in PTs and MLNs, and the clinical and pathological implications were analyzed by statistical methods. In PTs, the expression of Cx43 and E-cadherin was significantly reduced, compared to adjacent normal tissues (P< 0.01). The expression of Cx43 and E-cadherin was significantly increased in MLNs compared with PTs (P< 0.01 andP< 0.01, for Cx43 and E-cadherin, respectively), and some Cx43 and E-cadherin-negative PTs developed Cx43 and E-cadherin-positive MLNs. Furthermore, reduced expression of both Cx43 and E-cadherin significantly correlated with poor differentiation, advanced TNM stage, and lymph note metastasis of gastric cancers. Cx43 and E-cadherin expression significantly correlated with each other. We concluded that concurrent reduction in Cx43 and E-cadherin may contribute to the occurrence of gastric cancer. However, concurrent increased expression of Cx43 and E-cadherin may contribute to the efficient metastasis of gastric cancer to the lymph nodes.