Selective Polymyositis Induced by Coxsackievirus BI in Mice
Selective Polymyositis Induced by Coxsackievirus BI in Mice
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柯萨奇病毒BI诱导的小鼠选择性多发性肌炎
DOI：
10.1093/infdis/140.2.239
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
P. Johnson
中科院分区：
文献类型：
--
作者：
C. Ray;L. Minnich;P. Johnson
一种高传代实验室柯萨奇病毒B1菌株接种到随机繁育的瑞士新生小鼠（COH小鼠）体内后，会产生一种独特的肌炎，主要影响髋伸肌，并在较小程度上影响后膝关节屈肌。同样接种的BALB/c或C3H小鼠未观察到这种效果。除了小鼠菌株的易感性差异外，还发现从感染患者中分离出的六种不同的低传代柯萨奇病毒B1“野”分离株在诱导这些病变的能力方面存在很大差异。因此，柯萨奇病毒B1可在小鼠模型中诱导肌群特异性的选择性肌炎，宿主遗传因素和病毒株的特性在肌炎的发病机制中起重要作用。
A high-passage laboratory strain of coxsackievirus B1 produced a unique myositis that predominantly and profoundly affected hip extensors and, to a lesser extent, hindquarter knee flexors when inoculated into a strain of random-bred newborn mice of Swiss origin (COH mice). The effect was not observed in BALB/c or C3H mice similarly inoculated. In addition to the differences in susceptibility of the mouse strains, it was found that six different low-passage "field" isolates of coxsackie-virus B1 isolated from infected patients varied considerably in their capability to induce these lesions. Thus, selective myositis which is muscle group-specific can be induced in a mouse model with coxsackievirus B1, and both genetic factors of the host and characteristics of the virus strain play a significant role in the pathogenesis of the myositis.