Neutrophil Development, Migration, and Function in Teleost Fish.
Neutrophil Development, Migration, and Function in Teleost Fish.
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DOI：
10.3390/biology4040715
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发表时间：
2015-11-06
期刊：
影响因子：
4.2
通讯作者：
Barreda DR
中科院分区：
文献类型：
--
作者：
Havixbeck JJ;Barreda DR
现在人们普遍认识到中性粒细胞是一种复杂的细胞，对宿主防御和维持体内平衡至关重要。此外，中性粒细胞可塑性等概念有助于定义这一组细胞的表型范围以及有助于其分化的生理条件。在此，我们讨论了硬骨鱼中性粒细胞生命的关键特征，包括它们的发育，向炎症部位的迁移，以及对病原体杀死和急性炎症控制的贡献。这些细胞在硬骨鱼中引发的有效抗微生物机制证明了它们在宿主防御中的长期进化贡献。此外，最近对它们在诱导细胞凋亡之前控制炎症的积极作用的见解强调了它们在这些早期脊椎动物中维持宿主完整性的重要性。总的来说，我们的目标是总结我们对硬骨鱼中这种细胞类型的理解的最新进展，并为这种造血谱系在宿主防御和损伤或感染后有效恢复体内平衡中的贡献提供进化背景。
It is now widely recognized that neutrophils are sophisticated cells that are critical to host defense and the maintenance of homeostasis. In addition, concepts such as neutrophil plasticity are helping to define the range of phenotypic profiles available to cells in this group and the physiological conditions that contribute to their differentiation. Herein, we discuss key features of the life of a teleost neutrophil including their development, migration to an inflammatory site, and contributions to pathogen killing and the control of acute inflammation. The potent anti-microbial mechanisms elicited by these cells in bony fish are a testament to their long-standing evolutionary contributions in host defense. In addition, recent insights into their active roles in the control of inflammation prior to induction of apoptosis highlight their importance to the maintenance of host integrity in these early vertebrates. Overall, our goal is to summarize recent progress in our understanding of this cell type in teleost fish, and to provide evolutionary context for the contributions of this hematopoietic lineage in host defense and an efficient return to homeostasis following injury or infection.