Bionanomanipulation Using Atomic Force Microscopy Understanding disease at the molecular level using a nanorobot.
Bionanomanipulation Using Atomic Force Microscopy Understanding disease at the molecular level using a nanorobot.
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DOI：
10.1109/mnano.2010.935968
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发表时间：
2010-03-01
影响因子：
1.6
通讯作者：
Sinha, Animesh A.
中科院分区：
文献类型：
--
作者：
Xi, Ning;Fung, Carmen Kar Man;Sinha, Animesh A.
本文介绍了一个基于afm的纳米机器人是如何在纳米尺度上可视化和量化生理和病理生理条件下细胞蛋白质相互作用的动态的。由于这些事件在分子水平上与许多危及生命或无法治愈的疾病的原因直接相关，因此开发基于afm的纳米机器人，可以在单分子水平上对生物物体进行成像和操作，是揭示疾病标志物和阐明疾病机制的新途径。
This paper explains how an AFM-based nanorobot was developed to visualize and quantify the dynamics of cell proteins interactions under physiological and pathophysiological conditions at the nanoscale. As these events are directly related at the molecular level to the causes of many life-threatening or incurable diseases, the development of an AFM-based nanorobot, which can image and manipulate biological objects at the single molecule level, is a novel approach to reveal disease markers and elucidate the disease mechanisms.