Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection
Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection
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DOI：
10.1111/hepr.12712
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发表时间：
2017-02-01
影响因子：
4.2
通讯作者：
Tanaka, Eiji
中科院分区：
文献类型：
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作者：
Ichikawa, Yuki;Joshita, Satoru;Tanaka, Eiji
目的血清糖基化紫藤凝集素阳性Mac-2结合蛋白（WFA（+）-M2 BP）是一种可靠的、无创的肝纤维化指标。本研究评估了WFA（+）-M2 BP诊断慢性B型肝炎病毒（HBV）感染患者肝纤维化的能力，并评估了WFA（+）-M2 BP作为肝细胞癌（HCC）发展的预测因子。方法回顾性评估了112例未经治疗的HBV相关慢性肝炎和肝硬化患者的血清WFA（+）-M2 BP值。（+）-M2 BP水平与肝纤维化程度显著相关（r=0.3725，P=0.001）。纤维化阶段F2、F3和F4的临界指数分别为0.94、1.26和1.26。对于诊断F2纤维化，WFA（+）-M2 BP的受试者工作特征曲线下面积为0.713，与其他非侵入性纤维化标志物（如透明质酸、IV型胶原7S、天冬氨酸转氨酶与血小板比率指数、纤维化-4指数、血清白蛋白和血小板计数）的受试者工作特征曲线下面积相当。多变量分析确定男性、WFA（+）-M2 BP 0.71、丙氨酸氨基转移酶80 IU/L和血小板计数
AimSerum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP) is a reliable, non-invasive marker of liver fibrosis. This study assessed the ability of WFA(+)-M2BP to diagnose liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and evaluated WFA(+)-M2BP as a predictor of hepatocellular carcinoma (HCC) development.MethodsSerum WFA(+)-M2BP values were retrospectively evaluated in 112 treatment-naive patients with HBV-related chronic hepatitis and cirrhosis who had undergone liver biopsy at our hospital.ResultsSerum WFA(+)-M2BP levels were significantly related with liver fibrosis (r=0.3725, P=0.001). Fibrosis stage F2, F3, and F4 had a cut-off index of 0.94, 1.26, and 1.26, respectively. For diagnosing F2 fibrosis, the area under the receiver-operating characteristic curve for WFA(+)-M2BP was 0.713 and comparable with those of other non-invasive fibrosis markers, such as hyaluronic acid, type IV collagen 7S, aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, serum albumin, and platelet count. Multivariate analysis identified male, WFA(+)-M2BP 0.71, alanine aminotransferase 80IU/L, and platelet count