Peptide YY inhibits pancreatic secretion by inhibiting cholecystokinin release in the dog.
Peptide YY inhibits pancreatic secretion by inhibiting cholecystokinin release in the dog.
复制标题
肽 YY 通过抑制狗体内缩胆囊素的释放来抑制胰腺分泌。
DOI：
10.1016/0016-5085(88)90621-x
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Thompson,JC
中科院分区：
文献类型：
--
作者：
Lluis,F;Gomez,G;Fujimura,M;GreeleyJr,GH;Thompson,JC
肽YY抑制由狗的胆囊收缩素、胰泌素或神经降压素刺激的胰腺外分泌（碳酸氢盐、水和蛋白质），但肽YY是否抑制刺激胰腺外分泌的肠肽的释放尚不清楚。用胃、胰腺和盲肠插管准备6只犬。在不同的日子，单剂量的油酸钠（3，6，7.5，9，12，15，或18 mmol/h），单独（对照）或与肽YY（25，50，100，200，或400 pmol/kg · h，i. v.）联合给药，持续90 min。我们用放射免疫法测定血浆胆囊收缩素-33/39、促胰液素、神经降压素和肽YY的水平。在输注肽YY期间，与对照值（5.6 ± 0.6）相比，胆囊收缩素的累积释放（3.3 ± 0.5 ng-[0-90] min/ml）显著降低（p < 0.05）。分泌素和神经降压素的释放不受影响。在对照组（r = 0.68）和肽YY处理组（r = 0.67）中，胆囊收缩素的释放与胰腺蛋白输出之间均发现正相关（p < 0.05）。十二指肠内或结肠内给予油酸钠后，肽YY的释放显著。这些研究表明，肽YY对犬胰腺蛋白分泌的抑制至少部分是通过抑制胆囊收缩素的释放来介导的。
Peptide YY inhibits the pancreatic exocrine secretion (bicarbonate, water, and protein) that is stimulated by cholecystokinin, secretin, or neurotensin in the dog, but whether peptide YY inhibits the release of gut peptides that stimulate pancreatic exocrine secretion is not known. Six dogs were prepared with gastric, pancreatic, and cecal cannulas. On separate days, a single dose of sodium oleate (3, 6, 7.5, 9, 12, 15, or 18 mmol/h) was given intraduodenally for 90 min, either alone (control) or in combination with peptide YY (25, 50, 100, 200, or 400 pmol/kg · h, i.v.). We measured plasma levels of cholecystokinin-33/39, secretin, neurotensin, and peptide YY by radioimmunoassay. During infusion of peptide YY, the integrated release of cholecystokinin (3.3 ± 0.5 ng-[0–90] min/ml) was decreased significantly (p < 0.05) when compared with control values (5.6 ± 0.6). Release of secretin and neurotensin was not affected. A positive correlation (p < 0.05) was found between the release of cholecystokinin and pancreatic protein output in both control (r = 0.68) and peptide YY-treated (r = 0.67) groups. Release of peptide YY was significant after intraduodenal or intracolonic administration of sodium oleate. These studies demonstrate that inhibition of pancreatic protein secretion by peptide YY in dogs is mediated, at least in part, by an inhibition of the release of cholecystokinin.