DOES THE SYMPATHETIC NERVOUS-SYSTEM INFLUENCE SINUS ARRHYTHMIA IN MAN - EVIDENCE FROM COMBINED AUTONOMIC BLOCKADE
DOES THE SYMPATHETIC NERVOUS-SYSTEM INFLUENCE SINUS ARRHYTHMIA IN MAN - EVIDENCE FROM COMBINED AUTONOMIC BLOCKADE
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DOI：
10.1113/jphysiol.1984.sp015476
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发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
SMITH, SE
中科院分区：
文献类型：
--
作者：
COKER, R;KOZIELL, A;SMITH, SE
本文用微机心电图系统研究了丁溴东莨菪碱和阿替洛尔单用及合用对正常人迷走神经和交感神经传出活动的影响。窦性心律失常定量为R-R间期的SD。丁溴东莨菪碱可减少窦性心律失常，在一些受试者中几乎完全消除，但阿替洛尔预处理未改变该终点。单独使用阿替洛尔延长了平均R-R间期，增加了窦性心律失常。显然，人的窦性心律失常仅通过迷走神经传出介导，但阿替洛尔通过中枢迷走神经紧张作用增加心律失常。
The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man were studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked ECG system. Sinus arrhythmia was quantitated as the SD of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. Apparently sinus arrhythmia in man is mediated through vagal efferents alone but atenolol increases the arrhythmia through a central vagotonic effect.