PLASMA CYTOKINES AFTER THERMAL-INJURY AND THEIR RELATIONSHIP TO INFECTION
PLASMA CYTOKINES AFTER THERMAL-INJURY AND THEIR RELATIONSHIP TO INFECTION
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DOI：
10.1097/00000658-199307000-00012
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发表时间：
1993-07-01
影响因子：
9
通讯作者：
PRUITT, BA
中科院分区：
文献类型：
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作者：
DROST, AC;BURLESON, DG;PRUITT, BA
目的探讨烧伤患者血浆细胞因子水平与感染、核心体温及相互间的关系。摘要背景与细胞因子如白介素1β(IL1β)、白介素6(IL6)、肿瘤坏死因子α(TNFpha)等细胞因子有关，这些细胞因子在各种炎症性疾病中的作用已被研究。方法采用双抗体夹心酶联免疫吸附试验(EL ISA)检测27例烧伤患者血浆中IL 1β、IL 6和TNFα水平。结果严重感染患者血浆IL 6和TNFα水平明显高于未感染患者，且感染死亡患者IL 6水平高于存活患者。IL-1β水平与感染无明显关系。IL-6、IL-1β与体温呈正相关。IL-6与IL-1β、IL-6与TNF-α、TNF-α与IL-1β呈显著正相关。结论IL-6、TNF-α参与了烧伤患者对感染的反应。
Objective The relationship of plasma cytokine levels to infection, core temperature, and to one another in patients with thermal injury was examined.Summary Background Data The response to infection has been associated with cytokines such as interleukin 1beta (IL1beta), interleukin 6 (IL6), and tumor necrosis factor alpha (TNFalpha), and these cytokines have been studied in various inflammatory diseases. The authors previously reported that patients with thermal injury have elevated IL1beta and IL6 plasma levels and that these cytokines may play different roles in the response to thermal injury.Methods IL1beta, IL6, and TNFalpha were measured by enzyme-linked immunosorbent assay (ELISA) in serial samples of plasma from 27 patients.Results IL6 and TNFalpha levels were increased in severely infected patients as compared to patients who remained free of infection, and the IL6 level was higher in infected patients who died than those who survived. There was no apparent relationship between IL1beta levels and infection. IL6 and IL1beta were positively correlated with core temperature. The correlations between IL6 and IL1beta, between IL6 and TNFalpha, and between TNFalpha and IL1beta were significant.Conclusions These results suggest that IL6 and TNFalpha play a role in the response of burned patients to infection.