New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix
New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix
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DOI：
10.1016/s0960-894x(02)00624-8
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发表时间：
2002-10-21
影响因子：
2.7
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Murakami, N;Ye, Y;Kobayashi, M
利用表达HIV-1病毒调控蛋白Rev的NES的裂变酵母，在生物测定的指导下，从缬草中分离出新的Rev-转运抑制剂valtrate(1)。Valtrate(1)也抑制了HIV-1病毒p-24的产生，但对宿主MT-4细胞没有任何细胞毒性。(C) 2002 Elsevier Science Ltd.版权所有。
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells. (C) 2002 Elsevier Science Ltd. All rights reserved.