Computational investigation of platelet thrombus mechanics and stability in stenotic channels
Computational investigation of platelet thrombus mechanics and stability in stenotic channels
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DOI：
10.1016/j.jbiomech.2021.110398
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发表时间：
2021-04-29
影响因子：
2.4
通讯作者：
Fogelson, Aaron
中科院分区：
文献类型：
--
作者：
Du, Jian;Aspray, Elise;Fogelson, Aaron
流动下血小板血栓的稳定性被认为强烈依赖于局部血液动力学和血栓的孔隙率、渗透性和弹性。采用两相连续介质模型研究狭窄通道中血栓稳定性的生物力学。它将血栓视为一种多孔的粘弹性材料，其运动方式与背景流体不同。动态凝块-流动相互作用通过摩擦阻力项建模。该模型明确跟踪血小板间分子键的形成和断裂，这直接决定了血栓的粘弹性，并控制其抵抗流体阻力的能力。我们表征了不同流速、孔隙率、粘合剂浓度和粘合剂类型的血栓的稳定性/脆弱性。(C)2021爱思唯尔有限公司保留所有权利。
The stability of a platelet thrombus under flow is believed to depend strongly on the local hemodynamics and on the thrombus' porosity, permeability, and elasticity. A two-phase continuum model is used to investigate the biomechanics of thrombus stability in stenotic channels. It treats the thrombus as a porous, viscoelastic material moving differently than the background fluid. The dynamic clot-flow interaction is modeled through a frictional drag term. The model explicitly tracks the formation and breaking of interplatelet molecular bonds, which directly determine the viscoelastic property of the thrombus and govern its ability to resist fluid drag. We characterize the stability/fragility of thrombi for various flow speeds, porosities, bond concentrations, and bond types. (C) 2021 Elsevier Ltd. All rights reserved.