Chemical network of the living human brain - Evidence of reorganization with aging
Chemical network of the living human brain - Evidence of reorganization with aging
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DOI：
10.1016/s0926-6410(00)00068-9
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发表时间：
2001-04-01
期刊：
影响因子：
--
通讯作者：
Apkarian, AV
中科院分区：
文献类型：
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作者：
Grachev, ID;Apkarian, AV
我们最近使用体内质子磁共振波谱（H-1 MRS）描述了人脑的化学网络特性。在另一项关于衰老的研究中，我们发现，直到三十岁之前，前额叶和感觉运动皮层中的化学物质浓度都在增加，而在三十岁之后，年轻到中年之间，同一大脑区域中的化学物质浓度随后下降。我们预计这些与年龄相关的化学浓度差异可能反映了衰老过程中大脑化学网络的重组。使用 H-1 MRS 和相关性分析，对年轻和中年组的所有区域化学物质在脑区域内和脑区域之间的化学连接模式以及每种化学类型的化学连接的特定模式进行了检查。对于所有研究的年龄，主要的正相关发生在大脑区域内，而负相关则出现在大脑区域之间。然而，中年组大脑各区域的负化学连接模式较弱（F=40.4，P
We recently described the chemical network properties of the human brain using in vivo proton magnetic resonance spectroscopy (H-1 MRS). In a separate study of aging we found increased concentration of chemicals in the prefrontal and sensorimotor cortices up to the third decade of life, and subsequent decrease of chemical concentrations in the same brain regions after the third decade between young and middle age. We anticipated that these age-dependent differences in chemical concentrations might be a reflection of the chemical network reorganization of the brain during aging. The pattern of chemical connectivity within and across brain regions for all regional chemicals, and specific patterns of chemical connectivity for each chemical type were examined for young and middle age groups using H-1 MRS and correlation analysis. For all studied ages, the dominant positive correlations occurred within brain regions and negative correlations were seen across brain regions. However, the pattern of negative chemical connectivity across brain regions was weaker in middle-aged group (F=40.4, P