Azidofluoroalkylation of Alkenes with Simple Fluoroalkyl Iodides Enabled by Photoredox Catalysis
Azidofluoroalkylation of Alkenes with Simple Fluoroalkyl Iodides Enabled by Photoredox Catalysis
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DOI：
10.1021/acs.orglett.7b02056
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发表时间：
2017-09-15
期刊：
影响因子：
5.2
通讯作者：
Jiao, Ning
中科院分区：
文献类型：
--
作者：
Geng, Xiaoyu;Lin, Fengguirong;Jiao, Ning
描述了一种温和而有效的简单烯烃光氧化还原催化叠氮氟烷基化反应，使用易于获得的氟烷基碘。该方法允许从C=C部分直接和区域选择性地形成C-R-F和C-N-3键。可以将包括CF 3基团的各种氟代烷基选择性地引入到烯烃中以提供一系列β-氟烷基化叠氮化物。
A mild and efficient protocol for photoredox-catalyzed azidofluoroalkylation of simple alkenes is described with readily available fluoroalkyl iodides. This method allows for a direct and regioselective formation of C-R-F and C-N-3 bonds from the C=C moiety. A variety of fluoroalkyl groups including the CF3 group can be selectively introduced to olefins to afford a series of,beta-fluoroalkylated azides.