High-contact paternal occupations, infection and childhood leukaemia: five studies of unusual population-mixing of adults
High-contact paternal occupations, infection and childhood leukaemia: five studies of unusual population-mixing of adults
复制标题
DOI：
10.1038/bjc.1997.592
复制
发表时间：
1997-12-01
影响因子：
8.8
通讯作者：
Kinlen, LJ
中科院分区：
文献类型：
--
作者：
Kinlen, LJ
这一假设已经得到验证，即在与人口极端混合有关的儿童白血病发病率过高的情况下，从事与许多人（特别是儿童）接触的职业的男子的子女的发病率较高，如某些儿童感染所示。儿童白血病的数据进行了检查，从五个以前的研究，作者在其中发现显着的过度与人口混合涉及成人。职业职称根据估计的工作接触程度分为中等、高等、很高或不确定。与儿童频繁接触的职业被归类为接触水平非常高，因为高频率接触被假定为潜在的儿童白血病感染。有一个显著的积极趋势，（P < 0.001）在0-14岁的儿童白血病风险中，参考组的职业接触类别（包括中、低和不确定类别）（即高儿童）接触类别的综合数据，从作者的五项研究的成人人口混合; 0-4岁（P < 0.001）和5-14岁（P < 0.01）也有显著趋势。高接触率类别中的超额主要是因为父亲从事与建筑业和运输业有关的职业，这表明“非常高”接触率类别的定义更广泛。在英格兰和威尔士一般人群中使用儿童白血病死亡率数据对人口混合地区以外的问题进行有限的检查时，没有发现这些过度的迹象。这些发现代表了对儿童白血病感染的第一个基于个人的支持，这是由人口混合促进的，以及进一步支持成人在感染传播中的作用。
The hypothesis has been tested that, among excesses of childhood leukaemia associated with extreme population-mixing the incidence is higher for the children of men in occupations involving contact with many individuals (particularly children), as noted in certain childhood infections. Data on childhood leukaemia were examined from five previous studies of the author in which significant excesses had been found associated with population-mixing involving adults. Occupational titles were categorized according to the estimated level of work contacts as medium, high, Very high or indeterminate. Occupations involving frequent contact with children were categorized as having a very high contact level given the high frequency of exposure to the infection postulated as underlying childhood leukaemia. There was a significant positive trend (P < 0.001) in childhood leukaemia risk at ages 0-14 years across the occupational contact categories from the reference group (comprising the medium and low plus indeterminate categories) through high to very high (i.e. high-child) contact categories in the combined data from the author's five studies of adult population-mixing; this significant trend also applied at ages 0-4 (P < 0.001) and 5-14 (P < 0.01) years. The excess in the high category was mainly because of paternal occupations connected with the construction industry and transport, suggesting a broader definition of the 'very high' contact category. No sign of these excesses was found in a limited examination of the question outside areas of population-mixing using mortality data for childhood leukaemia in the general population of England and Wales. The findings represent the first individual-based support for infection underlying childhood leukaemia that is promoted by population-mixing, as well as further support for the role of adults in transmission of the infection.