MECHANISMS OF RAPID GROWTH IN THE NEONATAL PIG-HEART
MECHANISMS OF RAPID GROWTH IN THE NEONATAL PIG-HEART
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DOI：
10.1016/s0022-2828(08)80026-0
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发表时间：
1995-01-01
影响因子：
5
通讯作者：
MORGAN, HE
中科院分区：
文献类型：
--
作者：
BEINLICH, CJ;RISSINGER, CJ;MORGAN, HE
在出生后的头两周内，新生猪心的左心室游离壁生长迅速。从出生到14日龄，左心室游离壁（LVFW）质量从2.22 ± 0.10 g增加到9.62 ± 1.01 g，右心室游离壁（RVFW）从2.03 ± 0.24 g增加到3.56 ± 0.41 g。在同一时期，来自LVFW的肌细胞的细胞体积从1075 μ m（3）增加到3688 μ m（3），而来自RVFW的肌细胞的体积从1511 μ m（3）增加到2454 μ m（3）。在出生后的前2周，RVFW肌细胞的数量没有变化，而LVFW肌细胞的数量增加了28%，从出生到4-5日龄，来自两个心室的肌细胞约90%为单核细胞。到14日龄，67%的LVFW肌细胞和53%的RVFW肌细胞为多核细胞。当通过用马来酸依那普利处理仔猪来抑制心脏生长时，与来自未处理仔猪的心脏相比，LVFW质量在2周内减少了24%，并且由肌细胞体积的减少来解释。依那普利治疗没有改变心肌细胞的数量，无论是LVFW或RVFW相比，未经处理的仔猪的心脏。依那普利处理14天后，与未处理仔猪的心脏相比，LVFW中多核细胞的百分比降低，RVFW中无变化。这些结果表明，细胞肥大在很大程度上是新生猪心LVFW快速生长的原因，依那普利通过减少左心室肌细胞肥大来减少左心室的正常生长。
During the first 2 weeks of life the left ventricular free wall of the neonatal pig heart grows rapidly. The mass of the left ventricular free wall (LVFW) increased from 2.22 +/- 0.10 g to 9.62 +/- 1.01 g while the right ventricular free wall (RVFW) increased from 2.03 +/- 0.24 g to 3.56 +/- 0.41g from birth to 14 days of age. During the same period, the cellular volume of myocytes from the LVFW increased from 1075 mu m(3) to 3688 mu m(3) while myocytes from the RVFW increased in volume from 1511 mu m(3) to 2454 mu m(3), The number of RVFW myocytes did not change during the first 2 weeks of life, while the number of LVFW myocytes increased 28%, Myocytes from both ventricles were approximately 90% mononuclear from birth to 4-5 days of age, By 14 days, 67% of LVFW myocytes and 53% of RVFW myocytes were multinucleated. When growth of the heart was restrained by treatment of the piglet with enalapril maleate, the LVFW mass was reduced by 24% over 2 weeks compared to hearts from untreated piglets and was accounted for by a reduction in myocyte volume. Enalapril treatment did not alter the number of myocytes in either the LVFW or RVFW as compared to hearts from untreated piglets. After 14 days of enalapril treatment, the percentage of multinucleated cells was reduced in the LVFW and unchanged in the RVFW as compared to hearts from untreated piglets. These results indicate that cellular hypertrophy accounts in large part for the rapid growth of the LVFW of the neonatal pig heart and that enalapril reduced normal growth of the left ventricle by reducing left ventricular myocyte hypertrophy.