HYPOTHALAMIC CONCENTRATION AND RELEASE OF NEUROPEPTIDE-Y INTO MICRODIALYSATES IS REDUCED IN ANORECTIC TUMOR-BEARING RATS
HYPOTHALAMIC CONCENTRATION AND RELEASE OF NEUROPEPTIDE-Y INTO MICRODIALYSATES IS REDUCED IN ANORECTIC TUMOR-BEARING RATS
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DOI：
10.1016/0024-3205(94)90144-9
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发表时间：
1994-01-01
期刊：
影响因子：
6.1
通讯作者：
FISCHER, JE
中科院分区：
文献类型：
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作者：
CHANCE, WT;BALASUBRAMANIAM, A;FISCHER, JE
与自由喂养的对照组相比，患有厌食肿瘤的大鼠的下丘脑神经肽Y浓度显着降低，而匹配胴体重量对照大鼠的NPY水平显着升高。在出现厌食症之前，对荷瘤大鼠的下丘脑周围区域进行体内微透析，结果显示透析液中的 NPY 没有变化。然而，在出现厌食症后，与匹配的屠体重量或自由喂养的对照组相比，荷瘤大鼠的透析液中的 NPY 浓度显着降低。这些结果表明，在患有肛门肿瘤的大鼠中，下丘脑 NPY 浓度和释放选择性降低。由于 NPY 也会导致荷瘤大鼠的摄食减少，因此下丘脑 NPY 摄食机制的功能障碍可能在癌症厌食症中起首要作用。
Hypothalamic concentration of neuropeptide Y was decreased significantly in anorectic tumor-bearing rats, while NPY level was increased significantly in matched carcass weight control rats as compared with freely-feeding controls. In vivo microdialysis of the perifomical hypothalamic area of tumor-bearing rats prior to the development of anorexia revealed no alteration in NPY in dialysates. Following the development of anorexia, however, tumor-bearing rats exhibited significant reduction in NPY concentration in dialysates as compared with either matched carcass weight or freely-feeding control group. These results suggest that hypothalamic NPY concentration and release are decreased selectively in anorectic tumor-bearing rats. Since NPY also elicits less feeding in tumor-bearing rats, dysfunction of hypothalamic NPY feeding mechanisms may be of primary importance in cancer anorexia.