A biokinetic model for systemic technetium in adult humans
A biokinetic model for systemic technetium in adult humans
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DOI：
10.1088/0952-4746/35/2/297
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发表时间：
2015-06-01
影响因子：
1.5
通讯作者：
Giussani, A.
中科院分区：
文献类型：
--
作者：
Leggett, R.;Giussani, A.
本文回顾了锶在人体内的生物动力学数据，并提出了成人全身锶的生物动力学模型。参数值的开发侧重于高铁酸盐(TcO4-)的数据，这是最常见的锶形式，也是体液中预期存在的形式。该模型旨在作为职业或环境中锶摄入量的默认模型，即在没有特定形态或特定地点信息的情况下适用。模型中明确描述的组织包括甲状腺、唾液腺、胃壁、右结肠壁、肝脏、肾脏和骨骼。与国际放射防护委员会目前的职业或环境中氚摄入量的生物动力学模型(ICRP 1993,1994)相比，建议的模型提供了更详细和更符合生物现实的对锶的系统行为的描述，并基于更广泛的实验和医学数据。对于急性输注~(99m)Tc(T-1/2=6.02h)，对于两个模型中明确涉及的全身区域，当前ICRP模型所预测的累积(时间积分)活动与所提出的模型所预测的累积(时间积分)活动的比率在0.4-7之间。对于急性输注TC-99(T-1/2=2.1×10(5)年)，相应的比值范围为0.2-30。
This paper reviews biokinetic data for technetium and proposes a biokinetic model for systemic technetium in adult humans. The development of parameter values focuses on data for pertechnetate (TcO4-), the most commonly encountered form of technetium and the form expected to be present in body fluids. The model is intended as a default model for occupational or environmental intake of technetium, i.e. applicable in the absence of form-or site-specific information. Tissues depicted explicitly in the model include thyroid, salivary glands, stomach wall, right colon wall, liver, kidneys, and bone. Compared with the ICRP's current biokinetic model for occupational or environmental intake of technetium (ICRP 1993, 1994), the proposed model provides a more detailed and biologically realistic description of the systemic behaviour of technetium and is based on a broader set of experimental and medical data. For acute input of Tc-99m (T-1/2 = 6.02 h) to blood, the ratios of cumulative (time-integrated) activity predicted by the current ICRP model to that predicted by the proposed model range from 0.4-7 for systemic regions addressed explicitly in both models. For acute input of Tc-99 (T-1/2 = 2.1 x 10(5) year) to blood, the corresponding ratios range from 0.2-30.