Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents
Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents
复制标题
益生菌对肥胖儿童和青少年非酒精性脂肪性肝病的影响
DOI：
10.1097/mpg.0000000000001422
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发表时间：
2017-03-01
影响因子：
2.9
通讯作者：
Kelishadi, Roya
中科院分区：
文献类型：
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作者：
Famouri, Fatemeh;Shariat, Zainab;Kelishadi, Roya
目的：探讨益生菌对非酒精性脂肪性肝病（NAFLD）超声和生化指标的影响。他们被随机分配接受益生菌胶囊（含有嗜酸乳杆菌ATCC B3208，3 × 10（9）菌落形成单位[CFU];乳双歧杆菌DSMZ 32269，6 × 10（9）CFU;两歧双歧杆菌ATCC SD 6576，2 × 10（9）CFU;鼠李糖乳杆菌DSMZ 21690，2 × 10（9）CFU）或安慰剂12周。干预后，益生菌组的丙氨酸氨基转移酶平均水平从32.8（19.6）U/L降至23.1（9.9）U/L（P=0.02），天冬氨酸氨基转移酶平均水平从32.2（15.7）U/L降至24.3（7.7）U/L（P=0.02）。同样，干预组的平均胆固醇、低密度脂蛋白-C和甘油三酯以及腰围下降，体重、体重指数和体重指数z评分无显著变化。试验结束后，正常的肝脏超声检查报告在17（53.1%）和5（16.5%）的患者在干预和安慰剂groups.Conclusions：目前的研究结果表明，上述益生菌化合物的过程中可以有效地改善儿童NAFLD。
Objectives:This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (NAFLD).Methods:This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3x10(9) colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6x10(9) CFU; Bifidobacterium bifidum ATCC SD6576, 2x10(9) CFU; Lactobacillus rhamnosus DSMZ 21690, 2x10(9) CFU) or placebo for 12 weeks.Results:After intervention, in the probiotic group the mean levels of alanine aminotransferase decreased from 32.8 (19.6) to 23.1 (9.9) U/L (P=0.02) and mean aspartate aminotransferase decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P=0.02). Likewise the mean cholesterol, low-density lipoprotein-C, and triglycerides as well as waist circumference decreased in the intervention group, without significant change in weight, body mass index, and body mass index z score. After the trial, normal liver sonography was reported in 17 (53.1%) and 5 (16.5%) of patients in the intervention and placebo groups, respectively.Conclusions:The present findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.