The brain in chronic pain: clinical implications.
The brain in chronic pain: clinical implications.
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DOI：
10.2217/pmt.11.53
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发表时间：
2011-11-01
期刊：
影响因子：
1.7
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Apkarian AV
本文探讨了目前和潜在的未来，脑成像对慢性疼痛的影响。有人认为，慢性疼痛的新理论正在脱颖而出，特别是通过大脑成像的人类大脑在慢性疼痛。这些研究表明，大脑重组与慢性疼痛有关，以特定于临床疼痛类型的模式，大脑网络和受体靶点正在被识别，并反向转化为其功效和机制的动物研究。未来的研究需要整合人脑成像技术，以及更密集的反向翻译方法。
This article examines the present, and potential future, impact of brain imaging on chronic pain. It is argued that novel theories of chronic pain are coming to the fore, specifically through brain imaging of the human brain in chronic pain. Such studies show that the brain reorganizes in relation to chronic pain, in a pattern specific to the type of clinical pain, and that brain networks and receptor targets are being identified and reverse translated to animal studies of their efficacy and mechanisms. Future studies need to integrate across human brain imaging techniques, as well as more intensive reverse translational methods.