An update on avian influenza in Hong Kong 2002
An update on avian influenza in Hong Kong 2002
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DOI：
10.1637/0005-2086-47.s3.1083
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发表时间：
2003-01-01
期刊：
影响因子：
1.4
通讯作者：
Peiris, M
中科院分区：
文献类型：
--
作者：
Sims, LD;Guan, Y;Peiris, M
从2002年1月开始，香港爆发了由多种H5N1病毒基因引起的高致病性禽流感。在本地养鸡场感染病毒之前，在多个零售市场和主要家禽批发市场检测到病毒。2002年2月1日，在当地一个农场发现了第一例这种疾病。截至2002年2月9日，已有15个农场受到感染，到3月下旬，总共发现了22个受感染的农场。发现了三个主要的受感染农场集群，这表明病毒多次入侵，随后有限的横向传播到邻近的农场。通过检疫、加强生物安全措施以及减少受感染农场和接触者农场的人口，实现了对这种疾病的控制。大约95万只鸟被销毁。2002年4月，在感染持续存在的一个地区的农场引入了使用H5灭活疫苗的疫苗接种。分离出的病毒中没有一种含有1997年H5N1病毒的内部基因。
An outbreak of highly pathogenic avian influenza caused by multiple genotypes of H5N1 virus occurred in Hong Kong, commencing in January 2002. Infection in local chicken farms was preceded by the detection of virus in multiple retail markets and the main poultry wholesale market. The first case of this disease on a local farm was detected on February 1, 2002. By February 9, 2002, 15 farms were infected, and by late March a total of 22 infected farms had been identified. Three main clusters of infected farms were seen, suggesting multiple incursions of virus, and subsequent limited lateral spread to neighboring farms. Control of this disease has been effected through a combination of quarantine, tightening of biosecurity measures, and depopulation of infected and contact farms. About 950,000 birds have been destroyed. Vaccination using a killed H5 vaccine was introduced in April 2002 to farms in one zone where infection has persisted. None of the viruses isolated contained the internal genes found in the 1997 H5N1 virus.