OPTICAL COHERENCE TOMOGRAPHY
OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1126/science.1957169
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发表时间：
1991-11-22
期刊：
影响因子：
56.9
通讯作者：
FUJIMOTO, JG
中科院分区：
文献类型：
--
作者：
HUANG, D;SWANSON, EA;FUJIMOTO, JG
一种称为光学相干断层扫描（OCT）的技术已经被开发用于生物系统中的非侵入性横截面成像。OCT使用低相干干涉法以类似于超声脉冲回波成像的方式产生来自内部组织微结构的光学散射的二维图像。OCT具有几微米的纵向和横向空间分辨率，可以检测小至入射光功率约10（-10）的反射信号。断层成像显示在体外的视网膜和冠状动脉，两个临床相关的例子，分别是透明和混浊介质的代表性的乳头周围区域。
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructure in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.