Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
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DOI：
10.4049/jimmunol.1100660
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发表时间：
2011-08-15
期刊：
影响因子：
--
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Flies DB;Wang S;Xu H;Chen L
Upon interaction with B7 homolog 1, Programmed Death-1 transmits a critical co-inhibitory signal to T cells to negatively regulate immune responses. By extensively searching the genomic database with the immunoglobulin variable region of PD-1, we identified a homolog and named it Programmed Death-1 homolog (PD-1H). PD-1H is broadly expressed on the cell surface of hematopoietic cells, and could be further upregulated on CD4+ and CD8+ T cells following activation. We have generated a monoclonal antibody against PD-1H, which strikingly prevents acute graft versus host disease (GVHD) in semi- and fully-allogeneic murine models, leading to full chimerism following treatment. GVHD remains a primary hindrance to successful allogeneic hematopoietic cell transplantation therapy for the treatment of hematologic malignancy. Therefore, manipulation of PD-1H function may provide a new modality for controlling T cell responses to allogeneic tissues in transplant medicine.
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DOI：
10.1084/jem.20100619
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wang L;Rubinstein R;Lines JL;Wasiuk A;Ahonen C;Guo Y;Lu LF;Gondek D;Wang Y;Fava RA;Fiser A;Almo S;Noelle RJ
通讯作者：
Noelle RJ
影响因子：
15.9
作者：
Wilcox, RA;Flies, DB;Chen, LP
通讯作者：
Chen, LP
影响因子：
15.3
作者：
Linsley, P S;Brady, W;Urnes, M;Grosmaire, L S;Damle, N K;Ledbetter, J A
通讯作者：
Ledbetter, J A
影响因子：
3.2
作者：
Paczesny S;Choi SW;Ferrara JL
通讯作者：
Ferrara JL
DOI：
10.1073/pnas.87.13.5031
发表时间：
1990-07-01
影响因子：
11.1
作者：
LINSLEY, PS;CLARK, EA;LEDBETTER, JA
通讯作者：
LEDBETTER, JA