Effect of selective internal radiation therapy and hepatic arterial chemotherapy on normal liver volume and spleen volume
Effect of selective internal radiation therapy and hepatic arterial chemotherapy on normal liver volume and spleen volume
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DOI：
10.1002/jso.1162
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发表时间：
2001-12-01
影响因子：
2.5
通讯作者：
Gray, BN
中科院分区：
文献类型：
--
作者：
Moroz, P;Anderson, JEM;Gray, BN
目的：为了确定选择性内部放射治疗（SIRT）和肝动脉化疗（HAC）对正常的肝脏体积和脾脏体积的患者接受这些治疗晚期liver cancer.Methods：在第三阶段的临床试验，以评估SIRT超过HAC的好处一组患者接受SIRT + HAC，而第二组只接受HAC。对本试验中所有在治疗前和治疗后3、6和12个月进行腹部CT扫描的患者进行了评价。计算每例患者的正常肝实质（NHP）体积、门静脉直径和脾脏体积的变化，并分析其显著趋势。平均NHP体积减少了17%（P = 0.001）接受SIRT + HAC的患者（N = 22）治疗后12个月，而仅用HAC治疗的患者（N = 15）的平均NHP体积在12个月时没有变化。两个治疗组的平均门静脉直径分别增加了9%，P = 0.048和P <0.001。脾体积平均增加48%（P
Objective: To determine the effect of selective internal radiation therapy (SIRT) and hepatic arterial chemotherapy (HAC) on normal liver volume and spleen volume in patients receiving these treatments for advanced liver cancer.Methods: In a phase III clinical trial to assess the benefit of SIRT over HAC one group of patients received SIRT + HAC while a second group received HAC only. All patients in this trial who had abdominal CT scans available before treatment, and at 3, 6, and 12 months after treatment were evaluated. Changes in normal hepatic parenchyma (NHP) volume, portal vein diameter and spleen volume were calculated for each patient and analysed for significant trends.Results: The mean NHP volume decreased by 17% (P = 0.001) 12 months after treatment among patients receiving SIRT + HAC (N = 22), while the mean NHP volume among patients treated with HAC only (N = 15) was unchanged at 12 months. The mean portal vein diameter increased by 9% in both treatment groups, P = 0.048 and P < 0.001, respectively. The mean spleen volume increased by 48% (P